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- Title
Clearance of Persistent Hepatitis B Virus Infection in Chinese Bone Marrow Transplant Recipients Whose Donors Were Anti—Hepatitis B Core— and Anti—Hepatitis B Surface Antibody—Positive.
- Authors
Lau, George K. K.; Liang, Raymond; Lee, Cheuk Kwong; Yuen, Siu Tsan; Hou, Jinlin; Lim, Wei Ling; Williams, Roger
- Abstract
Thirteen hepatitis B surface antigen—positive Chinese patients who received hepatitis B surface antibody—positive marrow (hepatitis B core antibody-positive or -negative: 6 and 7, respectively) via allogeneic bone marrow transplantation (BMT) were studied. After BMT, 4 recipients had serologic clearance of hepatitis B surface antigen from hepatitis B core antibody—positive marrow, but none of the recipients of hepatitis B core antibody—negative marrow had serologic clearance (P = .02). There was no significant difference in the donors' hepatitis B surface antibody titer before BMT for patients with or without serologic clearance of hepatitis B surface antigen (2255.2 ± 4244.0 vs. 854.2 ± 2306.7 mIU/mL; P = not significant). Adoptive immunity clearance of hepatitis B surface antigen was favored by hepatitis B core antibody positive—donor marrow and was not related to donor pre-BMT hepatitis B surface antibody titer.
- Publication
Journal of Infectious Diseases, 1998, Vol 178, Issue 6, p1585
- ISSN
0022-1899
- Publication type
Article