We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cross-Reactive Antibodies against Gangliosides and Campylobacter jejuni Lipopolysaccharides in Patients with Guillaln-Barré or Miller Fisher Syndrome.
- Authors
Jacobs, Bart C.; Hazenberg, Maarten P.; van Doorn, Pieter A.; Endtz, Hubert Ph.; van der Meché, Frans G. A.
- Abstract
Campylobacter jejuni was isolated from stool specimens of 3 patients with Miller Fisher syndrome (MFS) and 2 patients with Guillain-Barré syndrome (GBS). Anti-GQlb antibodies in serum from all MFS patients cross-reacted with sialidase-sensitive epitopes in the lipopolysaccharide fraction of C. jejuni from these 3 MFS patients. One GBS patient had anti-GMl antibodies that bound with lipopolysaccharide of C. jejuni from a control patient and from the other GBS patient without anti-GMl antibodies. This binding was inhibited by cholera toxin but not by pretreatment with sialidase. The C. jejuni isolate from the GBS patient with serum anti-GMl antibodies did not contain anti-GMl antibody-binding epitopes. Our results strongly support the hypothesis that anti-GQlb antibodies in MFS patients are induced during the antecedent C. jejuni infection. In GBS patients, mechanisms other than molecular mimicry may also be involved in the production of anti-GMl antibodies.
- Publication
Journal of Infectious Diseases, 1997, Vol 175, Issue 3, p729
- ISSN
0022-1899
- Publication type
Article