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- Title
Factors Associated with Invasive Lung Aspergillosis and the Significance of Positive Aspergillus Culture after Liver Transplantation.
- Authors
Kusne, Shimon; Cisneros, Julian Torre; Mañez, Rafael; Irish, William; Martin, Maureen; Fung, John; Simmons, Richard L.; Starzl, Thomas E.
- Abstract
From January 1981 to December 1990, 2180 patients underwent orthotopic liver transplantation at the University of Pittsburgh. Thirty-two patients (1.5%) were identified with invasive aspergillosis (29 lung, 2 intraabdominal, 1 meningitis). Of29 patients with invasive lung disease, only 23 (79%) had positive culture (Aspergillus fumigatus, 20; Aspergillus flavus, 3). Forty-eight variables were analyzed and compared in 23 patients with invasive disease with positive cultures and 9 patients with colonization only. The variables associated with pulmonary invasive disease, by univariate analysis, were surgical time (P = .03), presence of laparotomies (P = .02), higher creatinine level at time of Aspergillus isolation (P = .01), and use of OKT3 (P = .02). However, in a multivariate analysis, only the last two (creatinine, OKT3) were associated with invasive lung aspergillosis. Of4 patients with positive abdominal wound culture, 2 had local invasive aspergillosis. Therefore, positive cultures of Aspergillus organisms from respiratory secretions and wound drainage may represent invasive disease and should not be ignored.
- Publication
Journal of Infectious Diseases, 1992, Vol 166, Issue 6, p1379
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/166.6.1379