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- Title
Transfusion‐induced red blood cell alloimmunisation is unhampered in elderly patients.
- Authors
Oud, Josine A.; Evers, Dorothea; de Haas, Masja; de Vooght, Karen M. K.; van de Kerkhof, Daan; Som, Nel; Péquériaux, Nathalie C. V.; Hudig, Francisca; van der Bom, Johanna G.; Zwaginga, Jaap Jan
- Abstract
Considering this finding, preventing transfusion-induced RBC alloimmunisation by antigen matching should be similarly pursued for immunocompetent young and elderly patients. Transfusion-induced red blood cell alloimmunisation is unhampered in elderly patients With advancing age, adaptive immune responses undergo significant deteriorating changes resulting in a gradual decline of protective responses to infections and long-term immune memory vaccination responses.1-4 Considering the pathophysiology of red blood cell (RBC) alloimmunisation shares several aspects with vaccination responses, primary transfusion-induced RBC alloimmunisation may similarly deteriorate with advancing age.
- Subjects
ERYTHROCYTES; OLDER patients; BLOOD transfusion reaction; INFORMED consent (Medical law); RED blood cell transfusion
- Publication
British Journal of Haematology, 2022, Vol 199, Issue 2, pe1
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18374