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- Title
Current and emerging therapeutic approaches for T‐cell acute lymphoblastic leukaemia.
- Authors
Pocock, Rachael; Farah, Nadine; Richardson, Simon E.; Mansour, Marc R.
- Abstract
Summary: T‐cell ALL (T‐ALL) is an aggressive malignancy of T‐cell progenitors. Although survival outcomes in T‐ALL have greatly improved over the past 50 years, relapsed and refractory cases remain extremely challenging to treat and those who cannot tolerate intensive treatment continue to have poor outcomes. Furthermore, T‐ALL has proven a more challenging immunotherapeutic target than B‐ALL. In this review we explore our expanding knowledge of the basic biology of T‐ALL and how this is paving the way for repurposing established treatments and the development of novel therapeutic approaches.
- Subjects
THERAPEUTICS; LYMPHOBLASTIC leukemia; ACUTE leukemia; SURVIVAL rate
- Publication
British Journal of Haematology, 2021, Vol 194, Issue 1, p28
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.17310