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- Title
Pim‐2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.
- Authors
Teramachi, Jumpei; Hiasa, Masahiro; Oda, Asuka; Harada, Takeshi; Nakamura, Shingen; Amachi, Ryota; Tenshin, Hirofumi; Iwasa, Masami; Fujii, Shiro; Kagawa, Kumiko; Miki, Hirokazu; Kurahashi, Kiyoe; Yoshida, Sumiko; Endo, Itsuro; Haneji, Tatsuji; Matsumoto, Toshio; Abe, Masahiro
- Abstract
The article discusses research which showed that multiple myeloma (MM) tumour expansion in the bone lesions or PIM2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma. Topics discussed include PIM2 induced in bone marrow stromal cells in MM, inhibition of PIM can restore bone formation and suppress the tumour burden in MM animal models and PIM2 expressed in cathepsin K-positive mature osteoclasts on the surface of bone.
- Subjects
MULTIPLE myeloma; BONE tumors; OSTEOCLASTOGENESIS; OSTEOCLASTS; MESENCHYMAL stem cells
- Publication
British Journal of Haematology, 2018, Vol 180, Issue 4, p581
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.14388