We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Assembly of microarrays for genome-wide measurement of DNA copy number.
- Authors
Snijders, Antoine M.; Nowak, Norma; Segraves, Richard; Blackwood, Stephanie; Brown, Nils; Conroy, Jeffrey; Hamilton, Greg; Hindle, Anna Katherine; Huey, Bing; Kimura, Karen; Law, Sindy; Myambo, Ken; Palmer, Joel; Ylstra, Bauke; Yue, Jingzhu Pearl; Gray, Joe W.; Jain, Ajay N.; Pinkel, Daniel; Albertson, Donna G.
- Abstract
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log[sub 2] ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.
- Subjects
HUMAN genome; DNA microarrays
- Publication
Nature Genetics, 2001, Vol 29, Issue 3, p263
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng754