We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.
- Authors
Yasushi Furukawa; Takeshi Shimada; Hiroto Furuta; Shohei Matsuno; Akiko Kusuyama; Asako Doi; Masahiro Nishi; Hideyuki Sasaki; Tokio Sanke; Kishio Nanjo
- Abstract
<bold>Context: </bold>A genome-wide association study in the French population has detected that novel single-nucleotide polymorphisms (SNPs) in the IDE-KIF11-HHEX gene locus and the SLC30A8 gene locus are associated with susceptibility to type 2 diabetes.<bold>Objective: </bold>We investigated whether SNPs in these loci were associated with type 2 diabetes in Japanese.<bold>Design: </bold>Two SNPs, rs7923837 and rs1111875, in the IDE-KIF11-HHEX gene locus and one SNP, rs13266634, in the SLC30A8 gene locus were genotyped in Japanese type 2 diabetic patients (n = 405) and in nondiabetic control subjects (n = 340) using the TaqMan genotyping assay system.<bold>Results: </bold>The G allele of rs7923837 was associated with type 2 diabetes [odds ratio 1.66, 95% confidence interval (CI) 1.28-2.15; P = 0.00014], following the same tendency as in the French population of the previous report. Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16; P = 0.0050) and 3.16 (95% CI 1.40-7.16; P = 0.0038) relative to noncarriers. Although the G allele was a major allele (66.5%) in the French population, it was a minor allele (23.8%) in Japanese. The G allele of rs1111875 was also associated with type 2 diabetes (odds ratio 1.42, 95% CI 1.13-1.78; P = 0.0024). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.31 (95% CI 0.97-1.77; P = 0.0810) and 2.40 (95% CI 1.34-4.32; P = 0.0028) relative to noncarriers. A significant association with type 2 diabetes was not observed for rs13266634.<bold>Conclusions: </bold>Polymorphisms in the IDE-KIF11-HHEX gene locus are associated with susceptibility to type 2 diabetes across the boundary of race.
- Subjects
JAPAN; ALLELES; COMPARATIVE studies; DISEASE susceptibility; DNA; GENETIC polymorphisms; RESEARCH methodology; MEDICAL cooperation; TYPE 2 diabetes; POLYMERASE chain reaction; PROTEINS; PROTEOLYTIC enzymes; REGRESSION analysis; RESEARCH; TRANSCRIPTION factors; EVALUATION research; GENOTYPES
- Publication
Journal of Clinical Endocrinology & Metabolism, 2008, Vol 93, Issue 1, p310
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2007-1029