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- Title
ESTABLISHING THE REFERENCE RANGE FORT LYMPHOCYTES SUBPOPULATIONS IN ADULTS AND CHILDREN FROM BRAZIL.
- Authors
José Leite TORRES, Alex; Luiza Dias ANGELO, Ana; Oliveira SILVA, Márcio; de Carvalho BASTOS, Milena; Ferreira de SOUZA, Denise; Amarai INOCÊNCIO, Lflian; Alexandre Rodrigues de LEMOS, José; JUNIOR, Ruy S.; Cauduro de CASTRO, Andrea; Vianna Bonnini PALMA, Patricia; CECI, Loredana; Martins NETTO, Eduardo; BRITES, Carlos
- Abstract
In Brazil, the existing reference values for T-lymphocytes subsets are based on data originated in other countries. There is no local information on normal variation for these parameters in Brazilian adults and children. We evaluated the normal variation found in blood donors from five large Brazilian cities, in different regions, and in children living in Salvador, and Rio de Janeiro. All samples were processed by flow cytometry. The results were analyzed according to region, gender, and lifestyle of blood donors. A total of 641 adults (63% males), and 280 children (58% males) were involved in the study. The absolute CD3+, and CD4+ cells count were significantly higher for females (adults and children). Higher CD4+ cell count in adults was associated with smoking, while higher CD8+ count was found among female children. Higher counts, for all T-cells subsets, were detected in blood donors from southeast / south regions while those living in the northern region had the lowest values. Individuals from midwestern and northeastern regions had an intermediate count for all these cells subsets. However, these differences did not reach statistical significance. In Brazil, gender and smoking, were the main determinants of differences in T-lymphocytes reference values.
- Subjects
SICK children -- Psychology; ORGAN donation; BLOOD transfusion; FLOW cytometry; REFERENCE values; CYTOGENETICS
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2013, Vol 55, Issue 5, p323
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S0036-46652013000500005