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- Title
Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions.
- Authors
Pacelli, A.; Greenman, J.; Cawthorne, C.; Smith, G.
- Abstract
The role of cyclooxygenase (COX)-2 as a driving force in early tumourigenesis and the current interest in the combination of COX-2 inhibitors with standard therapy in clinical trials creates an urgent need to establish clinically relevant diagnostic tests for COX-2 expression. Molecular imaging using small-molecule probes radiolabelled for both positron emission tomography (PET) and single photon emission computed tomography (SPECT) offers the potential to meet this need, providing a minimally invasive readout for the whole disease burden. This review summarises current approaches to the radiolabelling of small-molecule COX-2 inhibitors and their analogues for PET and SPECT imaging, and gives an overview of their biological evaluation and likely success of clinical application.
- Subjects
CYCLOOXYGENASE genetics; RADIOLIGAND assay; CLINICAL trials; INVASIVE diagnosis; TOMOGRAPHY
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2014, Vol 57, Issue 4, p317
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3160