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- Title
In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids.
- Authors
Hong, Chanseok; Lee, Chongmu
- Abstract
Dimethyl sulfoxide porous silicon (DMSO-PSi) colloid in which DMSO was used as a surfactant suitable for inhibiting the agglomeration of PSi nanoparticles was prepared for use in cancer photothermotherapy. The photothermal effect of the DMSO-PSi colloid was found to be high enough to destroy cancer cells ( T = ∼52 °C). The mean particle size of the PSi nanoparticles in the DMSO-PSi colloid was 67 nm, which is low enough to flow through blood vessels without causing a blockage. The DMSO-PSi colloid in combination with an NIR laser resulted in a cell viability of 5.70 %, which is a sufficiently high cytotoxic effect.
- Subjects
IN vitro studies; PANCREATIC diseases; THERMOTHERAPY; PHOTOTHERAPY; DIMETHYL sulfoxide; SILICON; COLLOIDS; SURFACE active agents
- Publication
Lasers in Medical Science, 2014, Vol 29, Issue 1, p221
- ISSN
0268-8921
- Publication type
Article
- DOI
10.1007/s10103-013-1316-3