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- Title
Circulating preoperative testosterone level predicts unfavourable disease at radical prostatectomy in men with International Society of Urological Pathology Grade Group 1 prostate cancer diagnosed with systematic biopsies.
- Authors
Ferro, Matteo; Lucarelli, Giuseppe; de Cobelli, Ottavio; Vartolomei, Mihai Dorin; Damiano, Rocco; Cantiello, Francesco; Crocerossa, Fabio; Perdonà, Sisto; Del Prete, Paola; Cordima, Giovanni; Musi, Gennaro; Del Giudice, Francesco; Busetto, Gian Maria; Chung, Benjamin I.; Porreca, Angelo; Ditonno, Pasquale; Battaglia, Michele; Terracciano, Daniela
- Abstract
Purpose: The association between circulating total testosterone (T) levels and clinically significant PCa is still a matter of debate. In this study, we evaluated whether serum testosterone levels may have a role in predicting unfavorable disease (UD) and biochemical recurrence (BCR) in patients with clinically localized (≤ cT2c) ISUP grade group 1 PCa at biopsy. Methods: 408 patients with ISUP grade group 1 prostate cancer, undergone to radical prostatectomy and T measurement were included. The outcome of interest was the presence of unfavourable disease (UD) defined as ISUP grade group ≥ 3 and/or pT ≥ 3a. Results: Statistically significant differences resulted between serum testosterone values and ISUP grade groups (P < 0.0001). Significant correlation was found analyzing testosterone values versus age (P < 0.0001), and versus PSA (P = 0.008). BCR-free survival was significantly decreased in patients with low levels of testosterone (P = 0.005). These findings were confirmed also in the ISUP 1–2 subgroups (P = 0.01). ROC curve analysis showed that T outperformed PSA in predicting UD (AUC 0.718 vs AUC 0.525; P < 0.001) and was and independent risk factor for BCR. Conclusion: Our findings suggested that circulating total T was a significant predictor of UD at RP in patients with preoperative low- to intermediate-risk diseases, confirming the potential role of circulating androgens in preoperative risk assessment of PCa patients.
- Subjects
RADICAL prostatectomy; TESTOSTERONE; PROSTATE cancer; CANCER diagnosis; RECEIVER operating characteristic curves; PATHOLOGY
- Publication
World Journal of Urology, 2021, Vol 39, Issue 6, p1861
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-020-03368-9