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- Title
The Selenium and Vitamin E Cancer Prevention Trial.
- Authors
Klein, Eric A.; Lippman, Scott M.; Thompson, Ian M.; Goodman, Phyllis J.; Albanes, Demetrius; Taylor, Philip R.; Coltman, Charles
- Abstract
Background. Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men. Materials and methods. The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. Results. Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2×2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower. Conclusions. SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.
- Subjects
PROSTATE cancer; CLINICAL trials; VITAMIN E; SELENIUM; CHEMOPREVENTION; PREVENTIVE medicine
- Publication
World Journal of Urology, 2003, Vol 21, Issue 1, p21
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-002-0314-z