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- Title
The Δ ccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe.
- Authors
Libert, Frédérick; Cochaux, Pascale; Beckman, Gunhild; Samson, Michel; Aksenova, Marina; Cao, Antonio; Czeizel, Andrew; Claustres, Mireille; de la Rúa, Concepción; Ferrari, Maurizio; Ferrec, Claude; Glover, Guillermo; Grinde, Bjorn; Güran, Sefik; Kucinskas, Vaidutis; Lavinha, Joao; Mercier, Bernard; Ogur, Gönül; Peltonen, Leena; Rosatelli, Cristina
- Abstract
Examines the function of DELTA ccr5 mutation against HIV-1 infection in Caucasian populations. Role of chemokine receptor genes in HIV-1 entry in human CD4-positive cells; Effect of monocytes and macrophages infected strains in viral transmission; Deletions in the gene segment that encodes the second extracellular loop.
- Subjects
GENETIC mutation; HIV infections; CAUCASIAN race
- Publication
Human Molecular Genetics, 1998, Vol 7, Issue 3, p399
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/7.3.399