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- Title
Functional complementation in mouse — human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8.
- Authors
Komatsu, Kenshi; Ohta, Tohru; Jinno, Yoshihiro; Nlikawa, Norio; Okumura, Yutaka
- Abstract
Fragments of human chromosome 8 were introduced into cells derived from murine scid mice via X-Irradiation and somatic cell fusion. The resulting hybrid clones contained human DNA fragment(s) which complemented the hyper-radlosensitivity of the scid cells. Alu-PCR products from these hybrids were used for chromosome painting using the technique of chromosome suppression hybridization, allowing assignment of the human (hyper-radlosensitivity of murine scid mutation, complementing) gene, a candidate for a V(D)J recombinase gene, to human chromosome 8q11.
- Publication
Human Molecular Genetics, 1993, Vol 2, Issue 7, p1031
- ISSN
0964-6906
- Publication type
Article