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- Title
Enhancing the interpretation of statistical P values in toxicology studies: implementation of linear mixed models (LMMs) and standardized effect sizes (SESs).
- Authors
Schmidt, Kerstin; Schmidtke, Jörg; Kohl, Christian; Wilhelm, Ralf; Schiemann, Joachim; Voet, Hilko; Steinberg, Pablo
- Abstract
In this paper, we compare the traditional ANOVA approach to analysing data from 90-day toxicity studies with a more modern LMM approach, and we investigate the use of standardized effect sizes. The LMM approach is used to analyse weight or feed consumption data. When compared to the week-by-week ANOVA with multiple test results per week, this approach results in only one statement on differences in weight development between groups. Standardized effect sizes are calculated for the endpoints: weight, relative organ weights, haematology and clinical biochemistry. The endpoints are standardized, allowing different endpoints of the same study to be compared and providing an overall picture of group differences at a glance. Furthermore, in terms of standardized effect sizes, statistical significance and biological relevance are displayed simultaneously in a graph.
- Subjects
TOXICITY testing; LINEAR statistical models; GENETICALLY modified foods; ANALYSIS of variance; NONPARAMETRIC estimation; TRANSGENIC organisms; TRANSGENIC plants; CLINICAL biochemistry
- Publication
Archives of Toxicology, 2016, Vol 90, Issue 3, p731
- ISSN
0340-5761
- Publication type
Article
- DOI
10.1007/s00204-015-1487-8