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- Title
Changes in Arachidonic Acid Metabolite Patterns in Alloxan-Induced Diabetic Rats.
- Authors
Hui, S.-C.G.; Ogle, C.W.; Wang, Z.; An, Y.; Hu, Y.-H.
- Abstract
The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was significantly weaker in 2-week postalloxan-treated rats. Indometacin abolished arachidonic-acid-induced depressor responses in both normal and diabetic animals. Hypotension induced by sodium nitroprusside was of the same magnitude in non-diabetic and insulin deficient rats. Plasma levels of thromboxane B2 were significantly increased in both the 1- and 2-week diabetic rats, being greater in the latter group; those of 6-keto-PGF1α remained unchanged during the 2-week diabetic period. It is concluded that the attenuation by diabetes of depressor responses to arachidonic acid could be due to changes in the thromboxane/prostacyclin balance, with thromboxane formation being elevated whereas prostacyclin generation remains unaffected. Copyright © 1989 S. Karger AG, Basel
- Publication
Pharmacology, 1989, Vol 39, Issue 5, p291
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000138612