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- Title
Treatment of Advanced Primary Lung Cancer Associated with Malignant Pleural Effusion by the Combination of Immunotherapy and Chemotherapy.
- Authors
Miyao, Hiromi; Chou, Takaaki; Ito, Kazuhiko; Moriyama, Hiroyuki; Mitsuma, Satoshi; Wakabayashi, Masaya; Yoshizawa, Hirohisa; Arakawa, Masaaki
- Abstract
Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were marginal, and the protocol was well-tolerated and feasible. Furthermore, 4 cases were treated with the combination of systemic chemotherapy and adoptive immunotherapy. Of these, 3 cases responded well to the therapy and have shown a complete response for more than 20 months, indicating that adoptive immunotherapy together with chemotherapy might be a beneficial treatment for advanced lung cancer patients. Copyright © 1994 S. Karger AG, Basel
- Publication
Oncology, 1994, Vol 51, Issue 1, p87
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227317