We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Roles of F-box proteins in cancer.
- Authors
Wang, Zhiwei; Liu, Pengda; Inuzuka, Hiroyuki; Wei, Wenyi
- Abstract
F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins. Dysregulation of F-box protein-mediated proteolysis leads to human malignancies. Notably, inhibitors that target F-box proteins have shown promising therapeutic potential, urging us to review the current understanding of how F-box proteins contribute to tumorigenesis. As the physiological functions for many of the 69 putative F-box proteins remain elusive, additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F-box protein-targeted anticancer therapies.
- Subjects
PROTEIN research; UBIQUITINATION; PROTEOLYSIS; THERAPEUTIC use of proteins; NEOPLASTIC cell transformation; CANCER treatment
- Publication
Nature Reviews Cancer, 2014, Vol 14, Issue 4, p233
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc3700