We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.
- Authors
Martins Balbinot, Karolyny; Almeida Loureiro, Felippe José; Pereira Chemelo, Giordanna; Alves Mesquita, Ricardo; Pereira Cruz Ramos, Aline Maria; Jucá Ramos, Rommel Thiago; da Costa da Silva, Artur Luiz; Fernandes de Menezes, Sílvio Augusto; da Silva Kataoka, Maria Sueli; Alves Junior, Sergio de Melo; Viana Pinheiro, João de Jesus
- Abstract
Background: Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, the investigation of the role of stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important stem cell biomarkers. Methodology: To verify the expression of these proteins in tissue samples of AME, dentigerous cyst (DC) and dental follicle (DF), immunohistochemistry was performed and indirect immunofluorescence were performed on the human AME (AME-hTERT) cell line. Results: Revealed expression of SOX-2, NANOG and OCT4 in the tissue samples and AME-hTERT lineage. Greater immunostaining of the studied proteins was observed in AME compared to DC and DF (p < 0.001). Conclusions: The presence of biomarkers indicates a probable role of stem cells in the genesis and progression of AME.
- Subjects
STEM cells; AMELOBLASTOMA; SOX transcription factors; DENTIGEROUS cyst; PROTEIN expression
- Publication
PeerJ, 2023, p1
- ISSN
2167-8359
- Publication type
Article
- DOI
10.7717/peerj.14349