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- Title
Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma.
- Authors
Matta, Ajay; Tripathi, Satyendra Chandra; DeSouza, Leroi V.; Grigull, Jörg; Kaur, Jatinder; Chauhan, Shyam Singh; Srivastava, Anurag; Thakar, Alok; Shukla, Nootan Kumar; Duggal, Ritu; DattaGupta, Siddhartha; Ralhan, Ranju; Michael Siu, K.W.
- Abstract
Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography-mass spectrometry showed overexpression of heterogeneous ribonucleoprotein K (hnRNP K), a transformation-related RNA-binding protein, in leukoplakia in comparison with normal tissue. Herein, we investigated the clinical significance of hnRNP K in identification of oral leukoplakic lesions in early stages and as a prognostic marker in head-and-neck/oral squamous cell carcinomas (HNOSCCs). Immunohistochemical analysis of hnRNP K was performed in 100 HNOSCCs, 199 leukoplakias and 55 nonmalignant tissues and correlated with clinicopathologic parameters and disease prognosis over 6 years for HNOSCCs. hnRNP K nuclear expression increased from normal tissues to leukoplakia, and frank malignancy ( p < 0.001). Cytoplasmic hnRNP K increased significantly from leukoplakia to HNOSCCs ( p < 0.001) and was associated with poor prognosis of HNOSCCs ( p = 0.011) by Kaplan-Meier analysis. The most important finding of our follow-up study is that cytoplasmic hnRNP K is an independent predictor of disease recurrence in HNOSCC patients. In conclusion, nuclear hnRNP K may serve as a potential marker for early diagnosis, whereas its cytoplasmic accumulation can help to identify a subgroup of HNOSCC patients with poor prognosis, suggesting its putative utility in clinical management of HNOSCC. © 2009 UICC
- Publication
International Journal of Cancer, 2009, Vol 125, Issue 6, p1398
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.24517