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- Title
Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumour lymphatic-homing peptide LyP-1.
- Authors
Witt, Hendrik; Hajdin, Katarina; Iljin, Kristina; Greiner, Oliver; Niggli, Felix K.; Schäfer, Beat W.; Bernasconi, Michele
- Abstract
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to other tumour cell lines, but not to normal skeletal muscle cells and fibroblasts, were isolated from phage-displayed random peptide libraries. One peptide, named RMS-I (CQQSNRGDRKRC) contained the integrin-binding motif RGD and its binding was blocked by an antibody against α
- Publication
International Journal of Cancer, 2009, Vol 124, Issue 9, p2026
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.24170