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- Title
Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential.
- Authors
Longe, Harold O.; Romesser, Paul B.; Rankin, Andrew M.; Faller, Douglas V.; Eller, Mark S.; Gilchrest, Barbara A.; Denis, Gerald V.
- Abstract
Human B- or T-cell lymphoma lines and primary murine lymphomas were treated with DNA oligonucleotides homologous to the telomere (TTAGGG repeat; 'T-oligo'), either alone or in combination with standard, widely-used anticancer chemotherapeutic agents. T-oligo induces cell cycle arrest and apoptosis in cultured human or murine B or T-lymphoma cell lines and primary tumor cells, but exerts no detectable toxicity on normal human or murine primary lymphocytes. Exposure to T-oligo is hypothesized to mimic exposure of the 3′ telomere repeat sequence, activating the ataxia telangiectasia mutated kinase, which phosphorylates downstream effectors such as p53, but effects are not dependent solely on functional p53. T-oligo causes early S-phase arrest and cooperates well with G
- Publication
International Journal of Cancer, 2009, Vol 124, Issue 2, p473
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.23946