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- Title
Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case.
- Authors
Itagaki, Yuki; Fukunaga, Akira; Takano, Hironobu; Yamamoto, Kazuyuki; Nishigami, Kohei; Ichimura, Tatsunosuke; Manase, Hiroto; Obata, Masahiko; Kato, Tatsuya; Hirano, Satoshi
- Abstract
An 80-year-old man presented to our emergency department complaining of a mass on the right side of his chest and pain in the right flank of his back. A chest computed tomography (CT) scan showed a relatively heterogenous oval-shaped tumor measuring 7.5 × 6.0 cm eroded to the 8th rib, with slightly dense fluid accumulation inside and calcification of the tumor wall. A 1-month follow-up CT scan showed spontaneous shrinkage of the tumor. The tumor was completely excised from the thoracic wall and the wall was reconstructed with a polytetrafluoroethylene mesh. Pathological examination showed coagulation necrosis in the chest wall tumor, but immunohistochemical staining revealed murine double minute 2- and Cyclin-dependent kinase 4-positive cells with irregular nuclear size and bizarre morphology. Therefore, dedifferentiated liposarcoma (DDLPS) was the final pathological diagnosis. Remarkable infiltration of CD8+ lymphocytes into the tumor was observed, along with a 90% positive ratio for programmed cell death-ligand 1. The patient has been followed-up for 1 year without any recurrence, despite not receiving any additional treatment. Liposarcoma is one of the most common types of soft tissue sarcomas; however, spontaneous regression of primary DDLPS arising from the chest wall is extremely rare. Herein, we report a case of DDLPS primary to the chest wall with spontaneous regression, probably due to a spontaneously induced T cell response.
- Subjects
LIPOSARCOMA; PROGRAMMED death-ligand 1; SARCOMA; IMMUNOSTAINING; COMPUTED tomography; T cells
- Publication
Surgical Case Reports, 2023, Vol 9, Issue 1, p1
- ISSN
2198-7793
- Publication type
Case Study
- DOI
10.1186/s40792-023-01606-x