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- Title
Secondary Metabolites from Peucedanum tauricum Fruits.
- Authors
Sharma, Pushpendra; Khureja, Rajni Singh
- Abstract
From the essential oil of fruits of Peucedanum tauricum Bieb., two new guaiane type sesquiterpene hydrocarbons guaia-1(10),11-diene (1) and guaia-9,11-diene (2) were identified. The structures of 1 and 2 were assigned by 1D- and 2D-NMR analysis. The relative configurations of the new compounds were established by 2D-NOESY experiments while the absolute configurations were deduced through chemical correlations with (+)-g-gurjunene (9) and capillary GC analysis using modified cyclodextrins as the stationary phases. From the less volatile dichloromethane extract of the fruits, coumarins, viz. peucedanin (3), oxypeucedanin hydrate (4) and officinalin isobutyrate (5) were isolated. Compound 5 was confirmed to be 6-carbomethoxy-7-isobutyroxycoumarin by its 1D- and 2D-NMR data as well as by conversion into officinalin (7) by alkaline hydrolysis. Peuruthenicin, a positional isomer of officinalin, is assigned structure 8. Bergapten (6) was identified by its mass spectrum. This is the first report on the isolation of compounds 4 and 5 from P. tauricum.
- Subjects
UMBELLIFERAE; ESSENTIAL oils; PLANT metabolites; MASS spectrometry; CYCLODEXTRINS
- Publication
Journal of Drug Delivery & Therapeutics, 2018, Vol 8, Issue 6, p211
- ISSN
2250-1177
- Publication type
Article
- DOI
10.22270/jddt.v8i6.2048