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- Title
Radium-223 Dichloride (Ra-223) for the Treatment of Metastatic Castration-resistant Prostate Cancer: Optimizing Clinical Practice in Nuclear Medicine Centers.
- Authors
Oyen, Wim; Sundram, Francis; Haug, Alexander R.; Kairemo, Kalevi; Lewington, Valerie; Mäenpää, Hanna; Mortensen, Jann; Mottaghy, Felix; Virgolini, Irene; O'Sullivan, Joe M.; Wyndaele, Dirk
- Abstract
Options for the treatment of metastatic castration-resistant prostate cancer (mCRPC) have expanded significantly during the last decade, with six new agents receiving regulatory approval in Europe and the United States. One of these treatments is radium-223 dichloride (Ra-223), the first radiopharmaceutical to offer significant clinical benefits in patients with mCRPC, including prolonging overall survival. The availability of Ra-223 for treating mCRPC marks a paradigm shift in the role of therapeutic nuclear medicine from one of bone pain palliation into one of frontline treatment. As experience in the use of Ra-223 expands, it has become clear that it is vital for nuclear medicine specialists to understand the clinical profile of Ra-223 and where it fits in the treatment algorithm in order to optimize use of the treatment in clinical practice. Participation in the multidisciplinary team responsible for the management of mCRPC patients is essential to ensure appropriate selection of patients and the delivery of safe and effective care. Effective interaction with radiation safety authorities is also required to ensure that local policies reflect the low-risk profile of this life-prolonging treatment. This paper aims to encourage an exchange of best practice between nuclear medicine centers around the world, assisting centers as they initiate or expand their therapeutic services.
- Subjects
RADIUMTHERAPY; PROSTATE cancer treatment; RADIOPHARMACEUTICALS; NUCLEAR medicine research; RADIOTHERAPY
- Publication
Journal of OncoPathology, 2015, Vol 3, Issue 1, p1
- ISSN
2052-5931
- Publication type
Article
- DOI
10.13032/tjop.2052-5931.100121