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- Title
Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): Early detection and late stage distribution of protease-resistant prion protein.
- Authors
Balachandran, Aru; Harrington, Noel P.; Algire, James; Soutyrine, Andrei; Spraker, Terry R.; Jeffrey, Martin; González, Lorenzo; O'Rourke, Katherine I.
- Abstract
The article discusses the experimental transmission of chronic wasting disease (CWD) in red deer. The animals were euthanized and tested using 3 conventional immunological assays as well as mild to moderate neurological signs, weight loss and post-inoculation at 18-20 months were investigated. It indicates that tissues used for CWD diagnosis show strong abnormal prion (PrPCWD) accumulation, and determines that red deer are susceptible to oral challenge.
- Subjects
RED deer; CHRONIC wasting disease; COMMUNICABLE diseases in animals; ANIMAL vaccination; INFECTIONS in deer; INFECTIONS in Elk; HEPATIC encephalopathy; DISEASES; DISEASE risk factors; INFECTIOUS disease transmission
- Publication
Canadian Veterinary Journal / Revue Vétérinaire Canadienne, 2010, Vol 51, Issue 2, p169
- ISSN
0008-5286
- Publication type
Article