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- Title
Epidermal growth factor receptor-targeted therapy in locally advanced or metastatic squamous cell carcinoma of the penis.
- Authors
Carthon, Bradley C.; Ng, Chaan S.; Pettaway, Curtis A.; Pagliaro, Lance C.
- Abstract
Objective • To evaluate the safety and efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in patients with advanced penile or scrotal cancer. Patients and Methods • We retrospectively reviewed the charts of patients with penile or scrotal squamous cell carcinoma who had visited our tertiary cancer centre between 2002 and 2009, including their subsequent treatment and follow-up. • We collected details of EGFR-targeted therapy and clinical outcomes. Treatment-associated time-to-disease-progression (TTP), overall survival (OS), responses to therapy and toxicity were evaluated. Results • A total of 24 patients had received EGFR-targeted therapies, including cetuximab, erlotinib and gefitinib. The most common treatment given (to 67% of patients) was cetuximab combined with one or more cytotoxic drugs. • The most common adverse effect was skin rash (71%). The median (range) TTP and OS were 11.3 (1-40) and 29.6 (2-205) weeks, respectively. The OS time for patients with visceral or bone metastases was significantly shorter than it was for those without (24.7 vs 49.9 weeks, P = 0.013). • Among 17 patients treated with cetuximab alone or in combination with cisplatin, there were four partial responses (23.5%) including two patients with apparently chemotherapy-resistant tumours. Conclusions • Our results suggest that cetuximab has antitumour activity in metastatic penile cancer, and may enhance the effect of cisplatin-based chemotherapy. • Prospective studies of EGFR-targeted therapies in men with these tumours are warranted.
- Subjects
EPIDERMAL growth factor receptors; SQUAMOUS cell carcinoma; PENILE cancer; DISEASE progression; BONE metastasis; CISPLATIN
- Publication
BJU International, 2014, Vol 113, Issue 6, p871
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/bju.12450