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- Title
Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
- Authors
Cemil, Bengu Cevirgen; Yilmazer, Demet; Atas, Hatice; Cengiz, Fatma Pelin; Canpolat, Filiz; Alper, Murat; Gonul, Muzeyyen
- Abstract
Introduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. Material and methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.
- Subjects
LICHEN planus; ADRENOCORTICOTROPIC hormone; BODY surface area; ANTHROPOMETRY; HYPOTHALAMO-hypophyseal system; THERAPEUTICS
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2017, Vol 34, Issue 4, p322
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/ada.2017.69311