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- Title
Regulated exocytosis: a novel, widely expressed system.
- Authors
Borgonovo, Barbara; Cocucci, Emanuele; Racchetti, Gabriella; Podini, Paola; Bachi, Angela; Meldolesi, Jacopo
- Abstract
Electrophysiological studies in some secretory and non-secretory cells have identified an extensive form of calciuminduced exocytosis that is rapid (hundreds of milliseconds), insensitive to tetanus toxin and distinct from regulated secretion. We have now identified a marker of the process, desmoyokin-AHNAK, in a clonal derivative of the neuronal cell line, PC12. In resting cells, desmoyokin-AHNAK is localized within the lumen of specific vesicles, but appears on the cell surface during stimulation. Desmoyokin-AHNAK-positive vesicles exist in a variety of cells and tissues and are distinct from the endoplasmic reticulum, Golgi, trans-Golgi, endosomes and lysosomes, and from Glut4 and constitutive secretion vesicles. They seem to be involved in two models of plasmalemma enlargement: differentiation and membrane repair. We therefore propose that these vesicles should be called 'enlargosomes'.
- Subjects
EXOCYTOSIS; ELECTROPHYSIOLOGY
- Publication
Nature Cell Biology, 2002, Vol 4, Issue 12, p955
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb888