We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Characteristics of mucosal-associated invariant T cells and their roles in immune diseases.
- Authors
Chiba, Asako; Murayama, Goh; Miyake, Sachiko
- Abstract
Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T cells that express a semi-invariant T-cell receptor and are restricted by the major histocompatibility complex class I-related molecule 1 (MR1). MAIT cells recognize biosynthetic derivatives of the riboflavin synthesis pathway present in microbes. MAIT cells have attracted increased interest related to various immune responses because of their unique features including their abundance in humans, non-peptidic antigens and ability to respond to antigenic and non-antigenic stimuli. The numbers of circulating MAIT cells are decreased in many immune diseases such as multiple sclerosis, systemic lupus erythematosus and inflammatory bowel diseases. However, the remaining MAIT cells have an increased cytokine-producing capacity and activated status, which are related to disease activity. Additionally, MAIT cells have been observed at sites of inflammation including the kidneys, synovial fluid and intestinal mucosa. These findings suggest their involvement in the pathogenesis of immune diseases. In this mini-review, we summarize the recent findings of MAIT cells in human immune diseases and animal models, and discuss their role and potential as a therapeutic target.
- Subjects
VITAMIN B2; T cell receptors; T cells; INFLAMMATORY bowel diseases; MAJOR histocompatibility complex; SYNOVIAL fluid; SYSTEMIC lupus erythematosus; IMMUNOLOGIC diseases
- Publication
International Immunology, 2021, Vol 33, Issue 12, p775
- ISSN
0953-8178
- Publication type
Article
- DOI
10.1093/intimm/dxab070