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- Title
The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.
- Authors
Ren, Ziyou; Hsu, Derek; Silverberg, Nanette; Silverberg, Jonathan
- Abstract
Background: Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD). Objective: We sought to determine the inpatient burden and comorbidities of PAIBD. Methods: We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations. Results: The most common PAIBD with a primary admission was pemphigus (8.0 per million), whereas the most common secondary diagnosis of PAIBD was dermatitis herpetiformis (DH; 9.6 per million). Bullous pemphigoid (BP) was inversely associated with being female and having government or no insurance but positively associated with Black and Hispanic race/ethnicity and more chronic conditions. Pemphigus was associated with being female, Hispanic, having government or no insurance, and having a higher number of chronic conditions. DH was inversely associated with non-White race but positively associated with having government insurance and more chronic conditions. BP was associated with dialysis, hypertension, and diabetes. Pemphigus was associated with osteoarthritis, renal failure, hypothyroidism, and weight loss. DH was associated with herpes simplex virus infection, rheumatoid arthritis, and fungal, viral, and other skin infections. Conclusion: PAIBD are associated with a considerable inpatient burden and comorbid health conditions.
- Subjects
AUTOIMMUNE diseases; ETHNIC groups; HEMODIALYSIS; HERPES simplex; HISPANIC Americans; HOSPITAL care; PEMPHIGUS; RESEARCH funding; RHEUMATOID arthritis; SKIN diseases; STATISTICS; SURVEYS; TIME; COMORBIDITY; DATA analysis; MULTIPLE regression analysis; BULLOUS pemphigoid
- Publication
American Journal of Clinical Dermatology, 2017, Vol 18, Issue 2, p287
- ISSN
1175-0561
- Publication type
Article
- DOI
10.1007/s40257-017-0257-1