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- Title
Developmental Disabilities and Intracranial Abnormalities in Children with Symptomatic Cytomegalovirus and Cochlear Implants.
- Authors
Hart, Catherine K.; Wiley, Susan; Choo, Daniel I.; Eby, Christine; Tucker, Laura; Schapiro, Mark; Meinzen-Derr, Jareen
- Abstract
Objective. To examine the association of intracranial radiographic abnormalities and developmental measures with outcomes in children with congenital symptomatic cytomegalovirus (CMV) and cochlear implants (CI). Design/Methods. It was a retrospective review of 15 children implanted from 2004 to 2010. Preimplant nonverbal intelligence quotient/developmental quotient (IQ/DQ) and head circumference (HC) were obtained. Computed tomography and magnetic resonance imaging of the brain and post- CI audiometry and language assessments were reviewed. Results. Eleven children (73%) had cognitive delay. Most had >1developmental disability. Median IQ/DQ was 65 (23-90). All had imaging abnormalities. Most imaging abnormalities were in parietal (60%) and temporal (60%) lobes. Children with HC < 5th percentile had poorer median post-CI PTA (38 dB versus 27 dB, P = 0.02). Periventricular calcifications were associated with lower receptive (rb = -0.75, P = 0.03) and expressive (rb = -0.84, P = 0.008) language. Because IQ/DQ was associated with periventricular calcifications (rb = -0.53, P = 0.04) and small HC (rb = -0.73, P = 0.002), their relationships with language appear partially driven by IQ/DQ. Conclusions. The location of brain abnormalities appears to correlate with worse outcomes after CI. These findingsmay allow for more accurate counseling of parents regarding anticipated postimplantation performance.
- Subjects
DEVELOPMENTAL disabilities; COCHLEAR implants; CYTOMEGALOVIRUS diseases; AUDIOMETRY; SKULL abnormalities; CALCIFICATION; PARIETAL lobe
- Publication
ISRN Otolaryngology, 2012, p1
- ISSN
2090-5742
- Publication type
Article
- DOI
10.5402/2012/502746