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- Title
Association of Epidermal Growth Factor Receptor Mutations with Metastatic Presentations in Non-Small Cell Lung Cancer.
- Authors
Im Il Na; Jong Heon Park; Du Hwan Choe; Jin Kyung Lee; Jae Soo Koh
- Abstract
We performed this retrospective study to assess the association of epidermal growth factor receptor (EGFR) with metastatic presentations in advanced non-small cell lung cancer (NSCLC). The data from 125 patients with stage III or IV NSCLC were analyzed. We detected EGFR mutations in 36 NSCLC patients. EGFR mutations were predominant in never-smokers (P < .001), patients with adenocarcinomas (P < .001), and female patients (P < .001). When the metastatic sites were analyzed, pleural metastases were associated with a high incidence of EGFR mutations (P = .028). Particularly, pleural metastases with minimal effusion (PMME) were associated with EGFR mutational status (P = .001). Patients with N3 lesions were less likely to harbor EGFR mutations (P = .033). On multivariate analysis, N3 lesions (P = .017) and PMME (P < .001) remained significant factors for EGFR mutations. EGFR mutations may be associated with different presentations of pleural and N3 nodal metastases.
- Subjects
EPIDERMAL growth factor; GROWTH factors; METASTASIS; SMALL cell lung cancer; LUNG cancer
- Publication
ISRN Oncology, 2011, p1
- ISSN
2090-5661
- Publication type
Article
- DOI
10.5402/2011/756265