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- Title
Coenzyme Q<sub>10</sub> protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells.
- Authors
Muta-Takada, Keiko; Terada, Takatomo; Yamanishi, Haruyo; Ashida, Yutaka; Inomata, Shinji; Nishiyama, Toshio; Amano, Satoshi
- Abstract
Coenzyme Q10 (CoQ10), which has both energizing and anti-oxidative effects, is also reported to have antiaging action, e.g., reducing the area of facial wrinkles. However, the mechanism of its anti-aging activity is not fully established. Here, we examined the effect of CoQ10 on human dermal and epidermal cells. CoQ10 promoted proliferation of fibroblasts but not keratinocytes. It also accelerated production of basement membrane components, i.e., laminin 332 and type IV and VII collagens, in keratinocytes and fibroblasts, respectively; however, it had no effect on type I collagen production in fibroblasts. CoQ10 also showed protective effects against cell death induced by several reactive oxygen species in keratinocytes, but only when its cellular absorption was enhanced by pretreatment of the cells with highly CoQ10-loaded serum. These results suggest that protection of epidermis against oxidative stress and enhancement of production of epidermal basement membrane components may be involved in the antiaging properties of CoQ10 in skin. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
- Subjects
COENZYMES; OXIDATIVE stress; CELL death; KERATINOCYTES; FIBROBLASTS; BASAL lamina
- Publication
Biofactors, 2009, Vol 35, Issue 5, p435
- ISSN
0951-6433
- Publication type
Article
- DOI
10.1002/biof.56