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- Title
Trophic Factors in Neurodegenerative Disorders.
- Authors
Weis, Joachim; Saxena, Smita; Evangelopoulos, Maria E.; Kruttgen, Alex
- Abstract
Neuronal survival is dependent on continuous trophic stimulation by neurotrophic factors. Anterograde and retrograde transport of neurotrophic factors and their receptors within neurites is essential for the communication of these survival signals. Lack of neurotrophic input has been proposed as a pathomechanism leading to neurodegenerative disease. The present short review provides a summary of some of the recent data on neurotrophic factors in neurodegenerative disorders and describes how disturbances of axonal trafficking might deprive neurons from trophic input. IUBMB Life, 55: 00-00, 2003
- Subjects
NEURODEGENERATION; ALZHEIMER'S disease; PARKINSON'S disease; HUNTINGTON disease
- Publication
IUBMB Life, 2003, Vol 55, Issue 6, p353
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1080/1521654031000153021