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- Title
Losartan and Immune Checkpoint Inhibitors in Glioblastoma: An Appropriate Substitute for Steroids.
- Authors
Rangwala, Burhanuddin Sohail; Shakil, Areej; Mustafa, Muhammad Saqlain; Rangwala, Hussain Sohail; Fatima, Hareer; Siddiq, Mohammad Arham
- Abstract
This article discusses the potential use of Losartan, a blood pressure medication, as an alternative to steroids in the treatment of glioblastoma (GBM), a type of brain tumor. GBM is a challenging disease to manage, and current treatments have limited efficacy. Immune checkpoint inhibitors (ICIs) have shown promise in cancer treatment, but they have not been successful in GBM due to the development of cerebral edema. Steroids are used to control edema but can suppress the immune system, counteracting the benefits of ICIs. Researchers have found that Losartan may prevent edema induced by immunotherapy without suppressing the immune system. The study conducted on mouse models of GBM showed that Losartan, when combined with an ICI, significantly increased the life expectancy of the mice. These findings suggest that Losartan and ICIs could be a potentially groundbreaking approach to GBM therapy, offering hope for patients. Further investigation and clinical trials are needed to fully understand the potential of this treatment.
- Subjects
IMMUNE checkpoint inhibitors; BRAIN tumors; CEREBRAL edema; MATRIX metalloproteinases; IMMUNE checkpoint proteins; BLOOD-brain barrier; LIFE expectancy
- Publication
Annals of Neurosciences, 2024, Vol 31, Issue 3, p152
- ISSN
0972-7531
- Publication type
Article
- DOI
10.1177/09727531231191880