We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
ROLE OF NITRO-OXIDATIVE STRESS IN THE PATHOGENESIS OF EXPERIMENTAL RAT PERIODONTITIS.
- Authors
BOŞCA, ADINA BIANCA; MICLĂUŞ, VIOREL; ILEA, ARANKA; CÂMPIAN, RADU SEPTIMIU; RUS, VASILE; RUXANDA, FLAVIA; RAŢIU, CRISTIAN; UIFĂLEAN, ANA; PÂRVU, ALINA ELENA
- Abstract
Background and aims. Periodontitis is a common chronic adult condition that implicates oxidative damage to gingival tissue, periodontal ligament and alveolar bone. This study aimed at assessing the association between the nitro-oxidative stress and the periodontal tissues destructions in experimental rat periodontitis. Methods. Periodontitis was induced in 15 male albino rats by repetitive lesions to the gingiva adjacent to the inferior incisors, performed daily, for 16 days. On D1, D3, D6, D8, and D16 the onset and evolution of periodontitis were monitored by clinical and histopathological examinations; blood was collected and serum nitrooxidative stress was evaluated through total nitrites and nitrates, total oxidative status, total antioxidant capacity, and oxidative stress index. Results. The results demonstrated that there was a graded and continuous increase in serum levels of total nitrites and nitrates, total oxidative status and oxidative stress index, which was consistent with the severity of periodontal destructions during periodontitis progression. However, total antioxidant capacity was not significantly influenced by the disease progression. Conclusions. In experimental rat periodontitis, the systemic nitro-oxidative stress was associated with the severity of periodontal destructions assessed clinically and histopathologically. Therefore, systemic nitro-oxidative stress parameters might be used as diagnostic tools in periodontitis.
- Subjects
OXIDATIVE stress; PERIODONTITIS; CARCINOGENESIS
- Publication
Clujul Medical, 2016, Vol 89, Issue 1, p150
- ISSN
1222-2119
- Publication type
Article
- DOI
10.15386/cjmed-529