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- Title
Changes of polymorphonuclear granulocyte migration and lymphocyte proliferative responses in elite runners undergoing intense exercise.
- Authors
Espersen, G. T.; Toft, E.; Ernst, E.; Kaalund, S.; Grunnet, N.
- Abstract
The immunoregulatory effects of intense exercise were examined measuring polymorphonuclear granulocyte (PMN) migration under agarose, lymphocyte proliferative responses after mitogen stimulation (phytohemagglutinin P, concanavalin A and pokeweed mitogen) and complement activation (C3 conversion) in the peripheral blood of elite runners undergoing maximal exertion. Eleven elite middle- and long-distance runners were tested in a 5-km race on a running track. PMN migration activity towards autologous serum and FMLP as chemoattractants both increased after intense physical activity. The lymphocytes showed increased proliferative responses to the mitogen stimulation 2 h after the run compared with pre-exercise values, and normalized activity after 24 h. The total number of lymphocytes in the peripheral blood markedly decreased 2 h after the run and the number of leukocytes increased. A tendency to a decrease in complement C3 conversion-was observed after the run, but within the estimated normal area. Our findings suggest that intense physical activity influences the cellular immune system.
- Publication
Scandinavian Journal of Medicine & Science in Sports, 1991, Vol 1, Issue 3, p158
- ISSN
0905-7188
- Publication type
Article
- DOI
10.1111/j.1600-0838.1991.tb00289.x