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- Title
Examination of the MSX1 gene in patients with Parkinson’s disease.
- Authors
Deng, H.; Zhu, S. H.; Le, W. D.; Yang, H. R.; Lv, H. W.; Xu, H. B.; Xie, W. J.; Jankovic, J.
- Abstract
Background – Several genetic variants in transcription factor genes have been reported to be associated with Parkinson’s disease (PD). The muscle segment homeobox drosophila homolog of 1 gene ( MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study – To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods – We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results – No mutation in the MSX1 gene was identified in our cohort. Conclusions – Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
- Subjects
PARKINSON'S disease; TRANSCRIPTION factors; HUMAN genetic variation; ETIOLOGY of diseases; GENETIC polymorphisms; MSX genes
- Publication
Acta Neurologica Scandinavica, 2009, Vol 120, Issue 6, p442
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2009.01271.x