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- Title
MiR-30a and miR-200c differentiate cholangiocarcinomas from gastrointestinal cancer liver metastases.
- Authors
Park, Jun Won; Jeong, Jong Min; Cho, Kye Soo; Cho, Soo Young; Cheon, Jae Hee; Choi, Dong Ho; Park, Sang Jae; Kim, Hark Kyun
- Abstract
Prior studies have demonstrated the utility of microRNA assays for predicting some cancer tissue origins, but these assays need to be further optimized for predicting the tissue origins of adenocarcinomas of the liver. We performed microRNA profiling on 195 frozen primary tumor samples using 14 types of tumors that were either adenocarcinomas or differentiated from adenocarcinomas. The 1-nearest neighbor method predicted tissue-of-origin in 33 samples of a test set, with an accuracy of 93.9% at feature selection p values ranging from 10−4 to 10−10. According to binary decision tree analyses, the overexpression of miR-30a and the underexpression of miR-200 family members (miR-200c and miR-141) differentiated intrahepatic cholangiocarcinomas from extrahepatic adenocarcinomas. When binary decision tree analyses were performed using the test set, the prediction accuracy was 84.8%. The overexpression of miR-30a and the reduced expressions of miR-200c, miR-141, and miR-425 could distinguish intrahepatic cholangiocarcinomas from liver metastases from the gastrointestinal tract.
- Subjects
GASTROINTESTINAL cancer; LIVER cancer; LIVER metastasis; METASTASIS; DECISION making; INTRAHEPATIC bile ducts
- Publication
PLoS ONE, 2021, Vol 16, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0250083