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- Title
Reconstitution of the immune system after hematopoietic stem cell transplantation in humans.
- Authors
Storek, Jan; Geddes, Michelle; Khan, Faisal; Huard, Bertrand; Helg, Claudine; Chalandon, Yves; Passweg, Jakob; Roosnek, Eddy
- Abstract
Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
- Subjects
IMMUNE system; IMMUNITY; HEMATOPOIETIC stem cell transplantation; HEMATOPOIETIC system; NATURAL immunity; CELLULAR therapy; RETICULO-endothelial system
- Publication
Seminars in Immunopathology, 2008, Vol 30, Issue 4, p425
- ISSN
1863-2297
- Publication type
Article
- DOI
10.1007/s00281-008-0132-5