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- Title
Control of HIV infection by IFN-α: implications for latency and a cure.
- Authors
Bourke, Nollaig M.; Napoletano, Silvia; Bannan, Ciaran; Ahmed, Suaad; Bergin, Colm; McKnight, Áine; Stevenson, Nigel J.
- Abstract
Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active anti-retroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance.
- Subjects
TYPE I interferons; HIV prevention; THERAPEUTICS; HIV infections; IMMUNE response; THERAPEUTIC use of cytokines
- Publication
Cellular & Molecular Life Sciences, 2018, Vol 75, Issue 5, p775
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-017-2652-4