We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Progress Report: Antimicrobial Drug Discovery in the Resistance Era.
- Authors
Shinu, Pottathil; Mouslem, Abdulaziz K. Al; Nair, Anroop B.; Venugopala, Katharigatta N.; Attimarad, Mahesh; Singh, Varsha A.; Nagaraja, Sreeharsha; Alotaibi, Ghallab; Deb, Pran Kishore
- Abstract
Antibiotic resistance continues to be a most serious threat to public health. This situation demands that the scientific community increase their efforts for the discovery of alternative strategies to circumvent the problems associated with conventional small molecule therapeutics. The Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report (published in June 2021) discloses the rapidly increasing number of bacterial infections that are mainly caused by antimicrobial-resistant bacteria. These concerns have initiated various government agencies and other organizations to educate the public regarding the appropriate use of antibiotics. This review discusses a brief highlight on the timeline of antimicrobial drug discovery with a special emphasis on the historical development of antimicrobial resistance. In addition, new antimicrobial targets and approaches, recent developments in drug screening, design, and delivery were covered. This review also discusses the emergence and roles of various antibiotic adjuvants and combination therapies while shedding light on current challenges and future perspectives. Overall, the emergence of resistant microbial strains has challenged drug discovery but their efforts to develop alternative technologies such as nanomaterials seem to be promising for the future.
- Subjects
ANTI-infective agents; DRUG resistance; SMALL molecules; DRUG resistance in microorganisms; DRUG development; ANTIBIOTICS
- Publication
Pharmaceuticals (14248247), 2022, Vol 15, Issue 4, pN.PAG
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph15040413