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- Title
Proton therapy for low-grade gliomas: Results from a prospective trial.
- Authors
Shih, Helen A.; Sherman, Janet C.; Nachtigall, Lisa B.; Colvin, Mary K.; Fullerton, Barbara C.; Daartz, Juliane; Winrich, Barbara K.; Batchelor, Tracy T.; Thornton, Lauren T.; Mancuso, Sarah M.; Saums, Michele K.; Oh, Kevin S.; Curry, William T.; Loeffler, Jay S.; Yeap, Beow Y.
- Abstract
BACKGROUND In this prospective study, the authors evaluated potential treatment toxicity and progression-free survival in patients with low-grade glioma who received treatment with proton radiation therapy. METHODS Twenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy were enrolled in a prospective, single-arm trial of proton therapy. The patients received proton therapy at a dose of 54 Gy (relative biological effectiveness) in 30 fractions. Comprehensive baseline and regular post-treatment evaluations of neurocognitive function, neuroendocrine function, and quality of life (QOL) were performed. RESULTS All 20 patients (median age, 37.5 years) tolerated treatment without difficulty. The median follow-up after proton therapy was 5.1 years. At baseline, intellectual functioning was within the normal range for the group and remained stable over time. Visuospatial ability, attention/working memory, and executive functioning also were within normal limits; however, baseline neurocognitive impairments were observed in language, memory, and processing speed in 8 patients. There was no overall decline in cognitive functioning over time. New endocrine dysfunction was detected in 6 patients, and all but 1 had received direct irradiation of the hypothalamic-pituitary axis. QOL assessment revealed no changes over time. The progression-free survival rate at 3 years was 85%, but it dropped to 40% at 5 years. CONCLUSIONS Patients with low-grade glioma tolerate proton therapy well, and a subset develops neuroendocrine deficiencies. There is no evidence for overall decline in cognitive function or QOL. Cancer 2015;121:1712-1719. © 2015 American Cancer Society.
- Subjects
PROTON therapy; CLINICAL trials; GLIOMA treatment; DRUG toxicity; DISEASE progression; RADIOTHERAPY; SHORT-term memory
- Publication
Cancer (0008543X), 2015, Vol 121, Issue 10, p1712
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.29237