We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
HCV-Infected Donor Indices and the Course of Acute Hepatitis in Their Recipients.
- Authors
Mosley, J.W.; Operskalski, E.A.; Rawal, B.D.; Fiebig, E.W.; Busch, M.P.
- Abstract
Background: We intuitively assume that the larger the inoculum of a virus, the sooner symptoms and findings will appear. The latter are also likely to be more marked. We have sought further evidence by testing stored sera from the 1970s Transfusion-transmitted Viruses Study (TTVS). Methods: We studied 27 TTVS recipients infected with HCV after each was exposed to a single anti-HCV positive donor. We used data from TTVS itself, and from anti-HCV screening of stored sera in the 1990s. Donor and recipient HCV RNA were quantitated using Monitor 2.0 assay. Results: Pairwise Spearman correlation coefficients showed no relation between the donor HCV RNA and the interval to, or level of, the recipient's peak HCV RNA. It did correlate with the interval from transfusion to the recipient's first ALT ³90 IU/L (-0.48, p=0.01), and with the peak ALT (0.44, p=0.03). The donors' ALT values were statistically borderline in relation to the interval to first ALT 390 (-0.36, p=0.07), but very significantly related to the recipient's peak ALT (0.57, p=0.002). Neither donor RNA nor ALT levels correlated with the days to peak ALT or the occurrence of icterus (7 cases). Stepwise multivariate regression (Table below) showed that donor RNA was the independent predictor of the latent period to first ALT elevation, but donor ALT sufficed to predict the amount of recipient ALT abnormality. Conclusions: As expected, donor HCV RNA relates to the recipient's latent period to ALT elevation. Unexpectedly, donor ALT level more than donor RNA relates to recipient ALT values. Individual pairs of donors and recipients have in common the individual viral strain, which may vary in the extent of hepatic damage. This would explain the donor-recipient ALT association.
- Subjects
BLOOD donors; HEPATITIS C; DISEASES
- Publication
Transfusion, 2001, Vol 41, p76S
- ISSN
0041-1132
- Publication type
Article