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- Title
CHA<sub>2</sub>DS<sub>2</sub>-VASc Score is a Predictor of No-Reflow in Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Intervention.
- Authors
Ipek, Gokturk; Onuk, Tolga; Karatas, Mehmet B.; Gungor, Baris; Osken, Altug; Keskin, Muhammed; Oz, Ahmet; Tanik, Ozan; Hayiroglu, Mert Ilker; Yaka, Hale Yilmaz; Ozturk, Recep; Bolca, Osman
- Abstract
Thrombosis and distal embolization play crucial role in the etiology of no-reflow. CHA2DS2-VASc score is used to estimate the risk of thromboembolism in patients with atrial fibrillation. We tested the hypothesis that CHA2DS2-VASc can predict no-reflow among patients who underwent primary percutaneous coronary intervention (PCI). A total number of 2375 consecutive patients with ST-segment elevation myocardial infarction were assessed for the study. Patients were divided into 2 groups as no-reflow (n = 111) and control (n = 1670) groups according to post-PCI no-reflow status. CHA2DS2-VASc scores were calculated for all patients. CHA2DS2-VASc scores were significantly higher in the no-reflow group compared to the control group. After a multivariate regression analysis, CHA2DS2-VASc score remained as an independent predictor (odds ratio: 1.58, 95% confidence interval: 1.33-1,88, P < .001) of no-reflow. Receiver–operating characteristics analysis revealed the cutoff value of CHA2DS2-VASc score ≥2 as a predictor of no-reflow with a sensitivity of 66% and a specificity of 59%. Moreover, in-hospital mortality was also associated with significantly higher CHA2DS2-VASc scores. In conclusion, CHA2DS2-VASc score is associated with higher risk of no-reflow and in-hospital mortality rates in patients who underwent primary PCI.
- Subjects
MYOCARDIAL infarction treatment; THROMBOEMBOLISM risk factors; ATRIAL fibrillation; CHI-squared test; CONFIDENCE intervals; MULTIVARIATE analysis; MYOCARDIAL revascularization; PERFUSION; RISK assessment; T-test (Statistics); TRANSLUMINAL angioplasty; LOGISTIC regression analysis; MULTIPLE regression analysis; PREDICTIVE tests; RETROSPECTIVE studies; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; HOSPITAL mortality; CORONARY angiography; ODDS ratio; MANN Whitney U Test; DISEASE complications
- Publication
Angiology, 2016, Vol 67, Issue 9, p840
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319715622844