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- Title
The Spemann organizer and embryonic head induction.
- Authors
Niehrs, Christof
- Abstract
In this article the author talks about the Spemann organiser, which is a piece of tissue corresponding to the upper dorsal blastopore lip of the amphibian embryo, consisting of presumptive mesoderm and endoderm. The properties of the organizer were identified in 1926 by researchers Hans Spemann and Hilde Mangold when they showed that the transplanted dorsal lip is able to induce a twinned embryo in a receiving host. The entire concept of the organizer was at times considered something of an artefact when it was realized that agents as unspecific as methylene blue could bring about similar inductions. The view of organizer function changed dramatically when it was realized that these inducers act in a permissive fashion. They all antagonize signalling by bone morphogenetic proteins.
- Subjects
EMBRYOLOGY; BONE morphogenetic proteins; GROWTH factors; SPEMANN, Hans; CYTOKINES; METHYLENE blue
- Publication
EMBO Journal, 2001, Vol 20, Issue 4, p631
- ISSN
0261-4189
- Publication type
Article
- DOI
10.1093/emboj/20.4.631