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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance.
Published in:
Nature Medicine, 1999, v. 5, n. 11, p. 1298, doi. 10.1038/15256
By:
- Li, Yongsheng;
- Li, Xian Chang;
- Zheng, Xin Xiao;
- Wells, Andrew D.;
- Turka, Laurence A.;
- Strom, Terry B.
Publication type:
Article
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.
Published in:
Nature Medicine, 1999, v. 5, n. 11, p. 1303, doi. 10.1038/15260
By:
- Wells, Andrew D.;
- Li, Xian Chang;
- Li, Yongsheng;
- Walsh, Matthew C.;
- Zheng, Xin Xiao;
- Wu, Zihao;
- Nuñez, Gabriel;
- Tang, Aimin;
- Sayegh, Mohamed;
- Hancock, Wayne W.;
- Strom, Terry B.;
- Turka, Laurence A.
Publication type:
Article
Variant‐to‐gene mapping in human microglial cell models with CRISPR validation implicates RTFDC1 at the Alzheimer's disease 'CASS4' locus.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.053176
By:
- Burton, Elizabeth;
- Argenziano, Mariana;
- Cook, Kieona;
- Lu, Sumei;
- Manduchi, Elisabetta;
- Leonard, Michelle E;
- Hodge, Kenyaita M;
- Wang, Li‐San;
- Schellenberg, Gerard D.;
- Johnson, Matthew E;
- Pippin, James A;
- Wells, Andrew D;
- Anderson, Stewart A;
- Brown, Christopher D.;
- Grant, Struan F.A.;
- Chesi, Alessandra
Publication type:
Article
High‐resolution, genome‐wide, promoter‐focused Capture C in astrocytes implicates causal genes for Alzheimer's disease: Development of new models and analysis methods/novel assays and technologies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043368
By:
- Burton, Elizabeth;
- Argenziano, Mariana;
- Lu, Sumei;
- Su, Chun;
- Leonard, Michelle E.;
- Hodge, Kenyaita M.;
- Manduchi, Elisabetta;
- Schellenberg, Gerard D.;
- Wang, Li‐San;
- Johnson, Matthew E.;
- Pippin, James A.;
- Brown, Christopher D.;
- Wells, Andrew D.;
- Grant, Struan F.A.;
- Chesi, Alessandra
Publication type:
Article
P1‐019: HIGH‐RESOLUTION GENOMEWIDE PROMOTER‐FOCUSED CONNECTOME IMPLICATES MICROGLIA CAUSAL GENES FOR ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P238, doi. 10.1016/j.jalz.2019.06.044
By:
- Argenziano, Mariana;
- Manduchi, Elisabetta;
- Littleton, Sheridan;
- Leonard, Michelle E.;
- Su, Chun;
- Lu, Sumei;
- Hodge, Kenyaita M.;
- Pippin, James A.;
- Schellenberg, Gerard D.;
- Johnson, Matthew E.;
- Wells, Andrew D.;
- Grant, Struan F.A.;
- Chesi, Alessandra
Publication type:
Article
Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approaches.
Published in:
Human Genetics, 2021, v. 140, n. 10, p. 1441, doi. 10.1007/s00439-021-02326-8
By:
- Su, Chun;
- Pahl, Matthew C.;
- Grant, Struan F. A.;
- Wells, Andrew D.
Publication type:
Article
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.62206
By:
- Hammond, Reza K.;
- Pahl, Matthew C.;
- Chun Su;
- Cousminer, Diana L.;
- Leonard, Michelle E.;
- Sumei Lu;
- Doege, Claudia A.;
- Wagley, Yadav;
- Hodge, Kenyaita M.;
- Lasconi, Chiara;
- Johnson, Matthew E.;
- Pippin, James A.;
- Hankenson, Kurt D.;
- Leibel, Rudolph L.;
- Chesi, Alessandra;
- Wells, Andrew D.;
- Grant, Struan F. A.
Publication type:
Article
Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation.
Published in:
International Immunology, 2000, v. 12, n. 6, p. 833, doi. 10.1093/intimm/12.6.833
By:
- Schrum, Adam G.;
- Wells, Andrew D.;
- Turka, Laurence A.
Publication type:
Article
DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Published in:
Nucleic Acids Research, 2015, v. 43, n. 2, p. 1268, doi. 10.1093/nar/gku1373
By:
- Yongheng Chen;
- Chunxia Chen;
- Zhe Zhang;
- Chun-Chi Liu;
- Johnson, Matthew E.;
- Espinoza, Celso A.;
- Edsall, Lee E.;
- Bing Ren;
- Xianghong Jasmine Zhou;
- Grant, Struan F.A.;
- Wells, Andrew D.;
- Lin Chen
Publication type:
Article
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27001-4
By:
- Pahl, Matthew C.;
- Doege, Claudia A.;
- Hodge, Kenyaita M.;
- Littleton, Sheridan H.;
- Leonard, Michelle E.;
- Lu, Sumei;
- Rausch, Rick;
- Pippin, James A.;
- De Rosa, Maria Caterina;
- Basak, Alisha;
- Bradfield, Jonathan P.;
- Hammond, Reza K.;
- Boehm, Keith;
- Berkowitz, Robert I.;
- Lasconi, Chiara;
- Su, Chun;
- Chesi, Alessandra;
- Johnson, Matthew E.;
- Wells, Andrew D.;
- Voight, Benjamin F.
Publication type:
Article
Deacetylase inhibition promotes the generation and function of regulatory T cells.
Published in:
Nature Medicine, 2007, v. 13, n. 11, p. 1299, doi. 10.1038/nm1652
By:
- Ran Tao;
- de Zoeten, Edwin F.;
- Özkaynak, Engin;
- Chunxia Chen;
- Liqing Wang;
- Porrett, Paige M.;
- Bin Li;
- Turka, Laurence A.;
- Olson, Eric N.;
- Greene, Mark I.;
- Wells, Andrew D.;
- Hancock, Wayne W.
Publication type:
Article
Next steps in the identification of gene targets for type 1 diabetes.
Published in:
Diabetologia, 2020, v. 63, n. 11, p. 2260, doi. 10.1007/s00125-020-05248-8
By:
- Grant, Struan F. A.;
- Wells, Andrew D.;
- Rich, Stephen S.
Publication type:
Article
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types.
Published in:
Genome Biology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s13059-022-02691-1
By:
- Pahl, Matthew C.;
- Le Coz, Carole;
- Su, Chun;
- Sharma, Prabhat;
- Thomas, Rajan M.;
- Pippin, James A.;
- Cruz Cabrera, Emylette;
- Johnson, Matthew E.;
- Leonard, Michelle E.;
- Lu, Sumei;
- Chesi, Alessandra;
- Sullivan, Kathleen E.;
- Romberg, Neil;
- Grant, Struan F. A.;
- Wells, Andrew D.
Publication type:
Article
Effects of high-intensity interval training while using a breathingrestrictive mask compared to intermittent hypobaric hypoxia.
Published in:
Journal of Human Sport & Exercise, 2019, v. 14, n. 4, p. 821, doi. 10.14198/jhse.2019.144.11
By:
- BELLOVARY, BRYANNE N.;
- KING, KELLI E.;
- NUNEZ, TONY P.;
- MCCORMICK, JAMES J.;
- WELLS, ANDREW D.;
- BOURBEAU, KELSEY C.;
- FENNEL, ZACHARY J.;
- ZIDONG LI;
- JOHNSON, KELLY E.;
- MORIARTY, TERENCE;
- MERMIER, CHRISTINE M.
Publication type:
Article
Regulation of T Cell Differentiation and Alloimmunity by the Cyclin-Dependent Kinase Inhibitor p18ink4c.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0091587
By:
- Rowell, Emily A.;
- Wang, Liqing;
- Chunder, Neelanjana;
- Hancock, Wayne W.;
- Wells, Andrew D.
Publication type:
Article
Regulatory T cells suppress CD4<sup>+</sup> T cells through NFAT-dependent transcriptional mechanisms.
Published in:
EMBO Reports, 2014, v. 15, n. 9, p. 991, doi. 10.15252/embr.201338233
By:
- Shin, Daniel S;
- Jordan, Ayana;
- Basu, Samik;
- Thomas, Rajan M;
- Bandyopadhyay, Sanmay;
- Zoeten, Edwin F;
- Wells, Andrew D;
- Macian, Fernando
Publication type:
Article
Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS.
Published in:
Human Genetics, 2018, v. 137, n. 5, p. 413, doi. 10.1007/s00439-018-1893-0
By:
- Manduchi, Elisabetta;
- Williams, Scott M.;
- Chesi, Alessandra;
- Johnson, Matthew E.;
- Wells, Andrew D.;
- Grant, Struan F. A.;
- Moore, Jason H.
Publication type:
Article
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-09302-x
By:
- Chesi, Alessandra;
- Wagley, Yadav;
- Johnson, Matthew E.;
- Manduchi, Elisabetta;
- Chun Su;
- Sumei Lu;
- Leonard, Michelle E.;
- Hodge, Kenyaita M.;
- Pippin, James A.;
- Hankenson, Kurt D.;
- Wells, Andrew D.;
- Grant, Struan F. A.
Publication type:
Article
Canonical Notch signaling is required for bone morphogenetic protein‐mediated human osteoblast differentiation.
Published in:
Stem Cells, 2020, v. 38, n. 10, p. 1332, doi. 10.1002/stem.3245
By:
- Wagley, Yadav;
- Chesi, Alessandra;
- Acevedo, Parker K.;
- Lu, Sumei;
- Wells, Andrew D.;
- Johnson, Matthew E.;
- Grant, Struan F. A.;
- Hankenson, Kurt D.
Publication type:
Article
New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation.
Published in:
Nature Reviews Immunology, 2014, v. 14, n. 4, p. 261, doi. 10.1038/nri3625
By:
- Wells, Andrew D.;
- Morawski, Peter A.
Publication type:
Article
Cell-cycle regulation of T-cell responses – novel approaches to the control of alloimmunity.
Published in:
Immunological Reviews, 2003, v. 196, n. 1, p. 25, doi. 10.1046/j.1600-065X.2003.00080.x
By:
- Wells, Andrew D.
Publication type:
Article
Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.91392
By:
- Thomas, Rajan M.;
- Pahl, Matthew C.;
- Liqing Wang;
- Grant, Struan F. A.;
- Hancock, Wayne W.;
- Wells, Andrew D.
Publication type:
Article
T follicular helper cells in human efferent lymph retain lymphoid characteristics.
Published in:
2019
By:
- Vella, Laura A.;
- Buggert, Marcus;
- Manne, Sasikanth;
- Herati, Ramin S.;
- Sayin, Ismail;
- Kuri-Cervantes, Leticia;
- Brody, Irene Bukh;
- O'Boyle, Kaitlin C.;
- Kaprielian, Hagop;
- Giles, Josephine R.;
- Son Nguyen;
- Muselman, Alexander;
- Antel, Jack P.;
- Bar-Or, Amit;
- Johnson, Matthew E.;
- Canaday, David H.;
- Naji, Ali;
- Ganusov, Vitaly V.;
- Laufer, Terri M.;
- Wells, Andrew D.
Publication type:
journal article
Circulating markers of intestinal barrier injury and inflammation following exertion in hypobaric hypoxia.
Published in:
European Journal of Sport Science, 2023, v. 23, n. 10, p. 2002, doi. 10.1080/17461391.2023.2203107
By:
- McKenna, Zachary J.;
- Bellovary, Bryanne N.;
- Ducharme, Jeremy B.;
- Deyhle, Michael R.;
- Wells, Andrew D.;
- Fennel, Zachary J.;
- Specht, Jonathan W.;
- Houck, Jonathan M.;
- Mayschak, Trevor J.;
- Mermier, Christine M.
Publication type:
Article
Heat acclimation during low‐intensity exercise increases V̇O2max and Hsp72, but not markers of mitochondrial biogenesis and oxidative phosphorylation, in skeletal tissue.
Published in:
Experimental Physiology, 2021, v. 106, n. 1, p. 290, doi. 10.1113/EP088563
By:
- Mang, Zachary A.;
- Fennel, Zachary J.;
- Realzola, Rogelio A.;
- Wells, Andrew D.;
- McKenna, Zachary;
- Droemer, Christian;
- Houck, Jonathan M.;
- Nava, Roberto C.;
- Mermier, Christine M.;
- Amorim, Fabiano T.
Publication type:
Article
Variant to Gene Mapping to Discover New Targets for Immune Tolerance.
Published in:
Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.633219
By:
- Mehra, Parul;
- Wells, Andrew D.
Publication type:
Article
Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.
Published in:
Nature Communications, 2017, v. 8, n. 6, p. 15677, doi. 10.1038/ncomms15677
By:
- Layman, Awo Akosua Kesewa;
- Deng, Guoping;
- O'Leary, Claire E.;
- Tadros, Samuel;
- Thomas, Rajan M.;
- Dybas, Joseph M.;
- Moser, Emily K.;
- Wells, Andrew D.;
- Doliba, Nicolai M.;
- Oliver, Paula M.
Publication type:
Article
New Multisite Bioelectrical Impedance Device Compared to Hydrostatic Weighing and Skinfold Body Fat Methods.
Published in:
International Journal of Exercise Science, 2020, v. 13, n. 4, p. 1718, doi. 10.70252/dxjn8781
By:
- WELLS, ANDREW D.;
- BELLOVARY, BRYANNE N.;
- HOUCK, JONATHAN M.;
- DUCHARME, JEREMY B.;
- MASOUD, ABDULAZIZ A.;
- GIBSON, ANN L.;
- MERMIER, CHRISTINE M.
Publication type:
Article
No Effect of L-Arginine on Vascular Stiffness at Rest and During Reactive Hyperemia in Young Healthy Subjects.
Published in:
International Journal of Exercise Science, 2019, v. 12, n. 2, p. 556, doi. 10.70252/egxw8290
By:
- WELLS, ANDREW D.;
- SWANSON, GEORGE;
- FAHEY, THOMAS D.;
- SMITH, MICHAEL M.
Publication type:
Article
Osteoporosis GWAS-implicated DNM3 locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels.
Published in:
JBMR Plus, 2024, v. 8, n. 5, p. 1, doi. 10.1093/jbmrpl/ziae051
By:
- Kaur, Gurcharan;
- Pippin, James A;
- Chang, Solomon;
- Redmond, Justin;
- Chesi, Alessandra;
- Wells, Andrew D;
- Maerz, Tristan;
- Grant, Struan F A;
- Coleman, Rhima M;
- Hankenson, Kurt D;
- Wagley, Yadav
Publication type:
Article
CRISPR‐Cas9–Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS‐Implicated 'STARD3NL' Locus.
Published in:
JBMR Plus, 2021, v. 5, n. 9, p. 1, doi. 10.1002/jbm4.10531
By:
- Pippin, James A;
- Chesi, Alessandra;
- Wagley, Yadav;
- Su, Chun;
- Pahl, Matthew C;
- Hodge, Kenyaita M;
- Johnson, Matthew E;
- Wells, Andrew D;
- Hankenson, Kurt D;
- Grant, Struan F A
Publication type:
Article
B7-H3 promotes acute and chronic allograft rejection.
Published in:
European Journal of Immunology, 2005, v. 35, n. 2, p. 428, doi. 10.1002/eji.200425518
By:
- Wang, Liqing;
- Fraser, Christopher C.;
- Kikly, Kristine;
- Wells, Andrew D.;
- Han, Rongxiang;
- Coyle, Anthony J.;
- Chen, Lieping;
- Hancock, Wayne W.
Publication type:
Article
BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses.
Published in:
European Journal of Immunology, 2004, v. 34, n. 10, p. 2750, doi. 10.1002/eji.200425198
By:
- Ye, Qunrui;
- Wang, Liqing;
- Wells, Andrew D.;
- Tao, Ran;
- Han, Rongxiang;
- Davidson, Anne;
- Scott, Martin L.;
- Hancock, Wayne W.
Publication type:
Article
Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17089-5
By:
- Su, Chun;
- Johnson, Matthew E.;
- Torres, Annabel;
- Thomas, Rajan M.;
- Manduchi, Elisabetta;
- Sharma, Prabhat;
- Mehra, Parul;
- Le Coz, Carole;
- Leonard, Michelle E.;
- Lu, Sumei;
- Hodge, Kenyaita M.;
- Chesi, Alessandra;
- Pippin, James;
- Romberg, Neil;
- Grant, Struan F. A.;
- Wells, Andrew D.
Publication type:
Article
247-OR: Variant-to-Gene-Mapping Analyses Reveal a Role for Pancreatic Islet Cells in Conferring Genetic Susceptibility to Sleep-Related Traits.
Published in:
Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-247-OR
By:
- LASCONI, CHIARA;
- PAHL, MATTHEW C.;
- PIPPIN, JAMES A.;
- SU, CHUN;
- JOHNSON, MATTHEW;
- CHESI, ALESSANDRA;
- WELLS, ANDREW D.;
- KAESTNER, KLAUS H.;
- GRANT, STRUAN F.A.
Publication type:
Article
245-OR: CIS-Regulatory Architecture of Human ESC-Derived Hypothalamic Neuron Differentiation Aids in Variant-to-Gene Mapping of Type 2 Diabetes Related Traits.
Published in:
Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-245-OR
By:
- PAHL, MATTHEW C.;
- LITTLETON, SHERIDAN H.;
- DOEGE, CLAUDIA;
- HODGE, KENYAITA M.;
- LEONARD, MICHELLE;
- LU, SUMEI;
- HAMMOND, REZA;
- BOEHM, KEITH;
- LASCONI, CHIARA;
- SU, CHUN;
- CHESI, ALESSANDRA;
- PIPPIN, JAMES A.;
- JOHNSON, MATTHEW;
- WELLS, ANDREW D.;
- VOIGHT, BENJAMIN F.;
- LEIBEL, RUDOLPH;
- GRANT, STRUAN F.;
- COUSMINER, DIANA L.
Publication type:
Article
305-OR: Genomic Basis to Shared Influences on Pubertal Timing and Type 2 Diabetes.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-305-OR
By:
- COUSMINER, DIANA L.;
- MISHRA, RAJASHREE;
- ARGENZIANO, MARIANA A.;
- MANDUCHI, ELISABETTA;
- HODGE, KENYAITA M.;
- SU, CHUN;
- LEONARD, MICHELLE;
- LU, SUMEI;
- PIPPIN, JAMES A.;
- JOHNSON, MATTHEW;
- WELLS, ANDREW D.;
- CHESI, ALESSANDRA;
- VOIGHT, BENJAMIN F.;
- GRANT, STRUAN F.
Publication type:
Article

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