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Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
Published in:
2016
By:
- Taldone, Tony;
- Zatorska, Danuta;
- Ochiana, Stefan O.;
- Smith ‐ Jones, Peter;
- Koziorowski, Jacek;
- Dunphy, Mark P.;
- Zanzonico, Pat;
- Bolaender, Alexander;
- Lewis, Jason S.;
- Larson, Steven M.;
- Chiosis, Gabriela;
- Pillarsetty, Naga Vara Kishore
Publication type:
Other
A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 2010, v. 53, n. 1, p. 47, doi. 10.1002/jlcr.1689
By:
- Taldone, Tony;
- Zatorska, Danuta;
- Kang, Yanlong;
- Chiosis, Gabriela
Publication type:
Article
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
Published in:
2010
By:
- Marubayashi, Sachie;
- Koppikar, Priya;
- Taldone, Tony;
- Abdel-Wahab, Omar;
- West, Nathan;
- Bhagwat, Neha;
- Caldas-Lopes, Eloisi;
- Ross, Kenneth N.;
- Gönen, Mithat;
- Gozman, Alex;
- Ahn, James H.;
- Rodina, Anna;
- Ouerfelli, Ouathek;
- Yang, Guangbin;
- Hedvat, Cyrus;
- Bradner, James E.;
- Chiosis, Gabriela;
- Levine, Ross L.;
- Gönen, Mithat
Publication type:
journal article
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02842-3
By:
- Joshi, Suhasini;
- Gomes, Erica DaGama;
- Wang, Tai;
- Corben, Adriana;
- Taldone, Tony;
- Gandu, Srinivasa;
- Xu, Chao;
- Sharma, Sahil;
- Buddaseth, Salma;
- Yan, Pengrong;
- Chan, Lon Yin L.;
- Gokce, Askan;
- Rajasekhar, Vinagolu K.;
- Shrestha, Lisa;
- Panchal, Palak;
- Almodovar, Justina;
- Digwal, Chander S.;
- Rodina, Anna;
- Merugu, Swathi;
- Pillarsetty, NagaVaraKishore
Publication type:
Article
Full Characterization and some reactions of 1-(2-adamantyl)-3-(1-adamantyl)aziridin-2-one.
Published in:
Journal of Heterocyclic Chemistry, 2008, v. 45, n. 3, p. 803, doi. 10.1002/jhet.5570450327
By:
- Lengyel, István;
- Taldone, Tony;
- Lyons, Theresa;
- Cesare, Victor
Publication type:
Article
About 1-triphenylmethyl-3- tert-butylaziridinone and some of its reactions.
Published in:
Journal of Heterocyclic Chemistry, 2001, v. 38, n. 4, p. 997, doi. 10.1002/jhet.5570380432
By:
- Lengyel, István;
- Cesare, Victor;
- Karram, Halina;
- Taldone, Tony
Publication type:
Article
A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90).
Published in:
PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075446
By:
- Shahinas, Dea;
- Folefoc, Asongna;
- Taldone, Tony;
- Chiosis, Gabriela;
- Crandall, Ian;
- Pillai, Dylan R.
Publication type:
Article
Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using 89Zr-DFO-Trastuzumab.
Published in:
PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008859
By:
- Holland, Jason P.;
- Caldas-Lopes, Eloisi;
- Divilov, Vadim;
- Longo, Valerie A.;
- Taldone, Tony;
- Zatorska, Danuta;
- Chiosis, Gabriela;
- Lewis, Jason S.
Publication type:
Article
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
Published in:
Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06486-6
By:
- Kishinevsky, Sarah;
- Tai Wang;
- Rodina, Anna;
- Sun Young Chung;
- Chao Xu;
- Philip, John;
- Taldone, Tony;
- Joshi, Suhasini;
- Alpaugh, Mary L.;
- Bolaender, Alexander;
- Gutbier, Simon;
- Sandhu, Davinder;
- Fattahi, Faranak;
- Zimmer, Bastian;
- Shah, Smit K.;
- Chang, Elizabeth;
- Inda, Carmen;
- Koren 3rd, John;
- Saurat, Nathalie G.;
- Leist, Marcel
Publication type:
Article
Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.
Published in:
2015
By:
- Goldstein, Rebecca L.;
- Shao Ning Yang;
- Taldone, Tony;
- Chang, Betty;
- Gerecitano, John;
- Elenitoba-Johnson, Kojo;
- Shaknovich, Rita;
- Tam, Wayne;
- Leonard, John P.;
- Chiosis, Gabriela;
- Cerchietti, Leandro;
- Melnick, Ari;
- Yang, Shao Ning
Publication type:
journal article
Biomarker based targeting of the epichaperome as a novel therapeutic approach for Multiple Myeloma (MM).
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2019, v. 19, p. e126, doi. 10.1016/j.clml.2019.09.208
By:
- Lopes, Eloisi Caldas;
- Wang, Tai;
- Jayabalan, David;
- Monge, Jorge;
- Taldone, Tony;
- Contreras, Jorge;
- Yip, Winnie;
- Panchal, Palak;
- Sharma, Sahil;
- Digwal, Chander;
- Chiosis, Gabriela;
- Niesvizky, Ruben;
- Guzman, Monica
Publication type:
Article
Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90.
Published in:
PLoS Neglected Tropical Diseases, 2010, v. 4, n. 6, p. 1, doi. 10.1371/journal.pntd.0000714
By:
- Taldone, Tony;
- Gillan, Victoria;
- Sun, Weilin;
- Rodina, Anna;
- Patel, Pallav;
- Maitland, Kirsty;
- O'Neill, Kerry;
- Chiosis, Gabriela;
- Devaney, Eileen
Publication type:
Article
Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90.
Published in:
PLoS Neglected Tropical Diseases, 2010, v. 4, n. 6, p. 1, doi. 10.1371/journal.pntd.0000714
By:
- Taldone, Tony;
- Gillan, Victoria;
- Sun, Weilin;
- Rodina, Anna;
- Patel, Pallav;
- Maitland, Kirsty;
- O'Neill, Kerry;
- Chiosis, Gabriela;
- Devaney, Eileen
Publication type:
Article
Heat shock protein 90 in neurodegenerative diseases.
Published in:
Molecular Neurodegeneration, 2010, v. 5, p. 24, doi. 10.1186/1750-1326-5-24
By:
- Wenjie Luo;
- Weilin Sun;
- Taldone, Tony;
- Rodina, Anna;
- Chiosis, Gabriela
Publication type:
Article
Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity.
Published in:
Proteins, 2019, v. 87, n. 10, p. 869, doi. 10.1002/prot.25750
By:
- Huck, John D.;
- Que, Nanette L. S.;
- Sharma, Sahil;
- Taldone, Tony;
- Chiosis, Gabriela;
- Gewirth, Daniel T.
Publication type:
Article
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 11, p. 677, doi. 10.1038/nchembio.1335
By:
- Patel, Pallav D;
- Yan, Pengrong;
- Seidler, Paul M;
- Patel, Hardik J;
- Sun, Weilin;
- Yang, Chenghua;
- Que, Nanette S;
- Taldone, Tony;
- Finotti, Paola;
- Stephani, Ralph A;
- Gewirth, Daniel T;
- Chiosis, Gabriela
Publication type:
Article
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Published in:
Nature Chemical Biology, 2011, v. 7, n. 11, p. 818, doi. 10.1038/nchembio.670
By:
- Moulick, Kamalika;
- Ahn, James H;
- Zong, Hongliang;
- Rodina, Anna;
- Cerchietti, Leandro;
- Gomes DaGama, Erica M;
- Caldas-Lopes, Eloisi;
- Beebe, Kristin;
- Perna, Fabiana;
- Hatzi, Katerina;
- Vu, Ly P;
- Zhao, Xinyang;
- Zatorska, Danuta;
- Taldone, Tony;
- Smith-Jones, Peter;
- Alpaugh, Mary;
- Gross, Steven S;
- Pillarsetty, Nagavarakishore;
- Ku, Thomas;
- Lewis, Jason S
Publication type:
Article
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-14082-5
By:
- Inda, Maria Carmen;
- Joshi, Suhasini;
- Wang, Tai;
- Bolaender, Alexander;
- Gandu, Srinivasa;
- Koren III, John;
- Che, Alicia Yue;
- Taldone, Tony;
- Yan, Pengrong;
- Sun, Weilin;
- Uddin, Mohammad;
- Panchal, Palak;
- Riolo, Matthew;
- Shah, Smit;
- Barlas, Afsar;
- Xu, Ke;
- Chan, Lon Yin L.;
- Gruzinova, Alexandra;
- Kishinevsky, Sarah;
- Studer, Lorenz
Publication type:
Article
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma.
Published in:
Molecular Oncology, 2014, v. 8, n. 2, p. 323, doi. 10.1016/j.molonc.2013.12.005
By:
- Ambati, Srikanth R.;
- Lopes, Eloisi Caldas;
- Kosugi, Kohji;
- Mony, Ullas;
- Zehir, Ahmet;
- Shah, Smit K.;
- Taldone, Tony;
- Moreira, Andre L.;
- Meyers, Paul A.;
- Chiosis, Gabriela;
- Moore, Malcolm A.S.
Publication type:
Article

Found: 19

Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.

A facile and efficient synthesis of d<sub>6</sub>-labeled PU-H71, a purine-scaffold Hsp90 inhibitor.

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.

Full Characterization and some reactions of 1-(2-adamantyl)-3-(1-adamantyl)aziridin-2-one.

About 1-triphenylmethyl-3- tert-butylaziridinone and some of its reactions.

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting <i>Plasmodium falciparum</i> Hsp90 (PfHsp90).

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using <sup>89</sup>Zr-DFO-Trastuzumab.

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.

Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.

Biomarker based targeting of the epichaperome as a novel therapeutic approach for Multiple Myeloma (MM).

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90.

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90.

Heat shock protein 90 in neurodegenerative diseases.

Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity.

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma.